Glial Neoplasm

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Contents

More Specific Terms

Epidemiology

  • 50% of all primary brain neoplasms
  • most commonly occur in 4th-6th decade of life
  • grade 3 & 4 most commonly occur in patients 40-70 years

Genetics

Clinical-manifestations

Diagnostic-procedures

Radiology

  • low-grade gliomas appear lesions with

Staging

  • low grade, grows slowly
  • inevitably transforms into higher grade if left untreated

Management

More General Terms

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 15, 16, 17. American College of Physicians, Philadelphia 2009, 2012, 2015
  2. Kaloshi G et al. Supratentorial low-grade gliomas in older patients. Neurology 2009 Dec 15; 73:2093. PMID: [1]
  3. Smith JS, Chang EF, Lamborn KR et al Role of extent of resection in the long-term outcome of low-grade hemispheric gliomas. J Clin Oncol. 2008 Mar 10;26(8):1338-45 PMID: [2]
  4. Surma-aho O, Niemelä M, Vilkki J et al Adverse long-term effects of brain radiotherapy in adult low-grade glioma patients. Neurology. 2001 May 22;56(10):1285-90. PMID: [3]
  5. Weller M, Stupp R, Hegi ME et al Personalized care in neuro-oncology coming of age: why we need MGMT and 1p/19q testing for malignant glioma patients in clinical practice. Neuro Oncol. 2012 Sep;14 Suppl 4:iv100-8 PMID: [4]
  6. National Guideline Clearinghouse Low-grade astrocytomas and oligodendrogliomas. Alberta Health Services, Cancer Care ngc-guideline: [5]
    - The use of dexamethasone in patients with high grade gliomas. CancerControl Alberta ngc-guideline: [6]
    - The role of biopsy in the management of patients with presumed diffuse low grade glioma: a systematic review and evidence- based clinical practice guideline. American Association of Neurological Surgeons ngc-guideline: [7]
    - The role of imaging in the management of adults with diffuse low grade glioma: a systematic review and evidence-based clinical practice guideline. American Association of Neurological Surgeons ngc-guideline: [8]
    - The role of neuropathology in the management of patients with diffuse low grade glioma: a systematic review and evidence- based clinical practice guideline. American Association of Neurological Surgeons ngc-guideline: [9]
    - The role of surgery in the management of patients with diffuse low grade glioma: a systematic review and evidence-based clinical practice guideline. American Association of Neurological Surgeons ngc-guideline: [10]
    - Management of patients with recurrence of diffuse low grade glioma: a systematic review and evidence-based clinical practice guideline. American Association of Neurological Surgeons ngc-guideline: [11]
    - The role of emerging therapy in the management of patients with diffuse low grade glioma. American Association of Neurological Surgeons ngc-guideline: [12]
    - The role of initial chemotherapy for the treatment of adults with diffuse low grade glioma: a systematic review and evidence- based clinical practice guideline. American Association of Neurological Surgeons ngc-guideline: [13]
    - The role of radiotherapy in the management of patients with diffuse low grade glioma: a systematic review and evidence- based clinical practice guideline. American Association of Neurological Surgeons ngc-guideline: [14]

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