Chemotherapy

From

Jump to: navigation, search

Contents

More Specific Terms

Introduction

  • Treatment of disease with chemicals or pharmaceutical agents, generally used in reference to treatment of neoplastic disease.

Comparative-biology

Indications

  • curable by chemotherapy
  • chemotherapy is beneficial
  • chemotherapy may have some benefit

Contraindications

Adverse-effects

  • see specific agent
  • generally toxicity to rapidly dividing cells:

Mechanism-of-action

  • * Generally, chemotherapy effective on replicating cells.

  • Mechanism of chemotherapy failure:
  • decreased drug activation
  • increased drug inactivation
  • increased production of target enzyme
  • no age-associated resistance to chemotherapy [9]

Notes

More General Terms

Additional Terms

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015
  2. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 678-680
  3. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 527
  4. Bargou R et al. Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science 2008 Aug 15; 321:974. PMID: [1]
  5. Scholl C et al Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. Cell 2009 May 29; 137:821 PMID: [2]
    - Luo J et al A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell 2009 May 29; 137:835. PMID: [3]
  6. Weeks JC et al. Patients' expectations about effects of chemotherapy for advanced cancer. N Engl J Med 2012 Oct 25; 367:1616 PMID: [4]
    - Smith TJ and Longo DL. Talking with patients about dying. N Engl J Med 2012 Oct 25; 367:1651 PMID: [5]
  7. Smith EM et al Effect of Duloxetine on Pain, Function, and Quality of Life Among Patients With Chemotherapy-Induced Painful Peripheral Neuropathy. A Randomized Clinical Trial. JAMA. 2013;309(13):1359-1367 <PubMed> PMID: [6] <Internet> [7]
  8. Bolognia JL, Cooper DL, Glusac EJ. Toxic erythema of chemotherapy: a useful clinical term. J Am Acad Dermatol. 2008 Sep;59(3):524-9 PMID: [8]
  9. Geriatric Review Syllabus, 8th edition (GRS8) Durso SC and Sullivan GN (eds) American Geriatrics Society, 2013
  10. Hurria A, Togawa K, Mohile SG et al Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. J Clin Oncol. 2011 Sep 1;29(25):3457-65 PMID: [9]
  11. Daenen LGM et al Increased Plasma Levels of Chemoresistance-Inducing Fatty Acid 16:4(n-3) After Consumption of Fish and Fish Oil. JAMA Oncol. Published online April 02, 2015. <PubMed> PMID: [10] <Internet> [11]
  12. Yeh ET, Tong AT, Lenihan DJ et al Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management. Circulation. 2004 Jun 29;109(25):3122-31. PMID: [12]
  13. Navari RM, Aapro M. Antiemetic Prophylaxis for Chemotherapy-Induced Nausea and Vomiting. N Engl J Med 2016; 374:1356-1367. April 7, 2016 <PubMed> PMID: [13] <Internet> [14]
  14. Maggiore RJ, Dale W, Gross CP et al Polypharmacy and potentially inappropriate medication use in older adults with cancer undergoing chemotherapy: effect on chemotherapy-related toxicity and hospitalization during treatment. J Am Geriatr Soc. 2014 Aug;62(8):1505-12. PMID: Free PMC Article&dopt=Abstract
  15. Klepin HD, Pitcher BN, Ballman KV et al Comorbidity, chemotherapy toxicity, and outcomes among older women receiving adjuvant chemotherapy for breast cancer on a clinical trial: CALGB 49907 and CALGB 361004 (alliance). J Oncol Pract. 2014 Sep;10(5):e285-92. PMID: Free PMC Article&dopt=Abstract
  16. Geriatric Review Syllabus, 9th edition (GRS9) Medinal-Walpole A, Pacala JT, Porter JF (eds) American Geriatrics Society, 2016
  17. Kano M et al. AMH/MIS as a contraceptive that protects the ovarian reserve during chemotherapy. Proc Natl Acad Sci U S A 2017 Feb 28; 114:E1688. <PubMed> PMID: Free PMC Article&dopt=Abstract <Internet> [15]
    - Woodruff TK. A win-win for women's reproductive health: A nonsteroidal contraceptive and fertoprotective neoadjuvant. Proc Natl Acad Sci U S A 2017 Feb 28; 114:2101. <PubMed> PMID: &dopt=Abstract <Internet> [16]
  18. Uhl L, Assmann SF, Hamza TH et al. Laboratory predictors of bleeding and the effect of platelet and RBC transfusions on bleeding outcomes in the PLADO trial. Blood 2017 Sep 7; 130:1247 PMID: [17]
  19. Nelson R Community Cancer Care 'Much Cheaper' Than Hospital Medscape - Oct 11, 2017. [18]
    - The Value of Community Oncology. Site of Care Cost Analysis. Xcenda. Sept 25, 2017 [19]
  20. Cancer Chemotherapy: NIH Institute and Center Resources [20]
  21. National Guideline Clearinghouse
    - American Society of Clinical Oncology 2008 clinical practice guideline update: use of chemotherapy and radiation therapy protectants ngc-guideline: [21]
    - Guideline for the prevention of acute chemotherapy-induced nausea and vomiting in pediatric cancer patients: a focused update. Pediatric Oncology Group of Ontario ngc-guideline: [22]
    - Safe administration of systemic cancer therapy. Part 2: administration of chemotherapy and management of preventable adverse events. Program in Evidence-based Care ngc-guideline: [23]
    - Approach to fever assessment in ambulatory cancer patients receiving chemotherapy. Program in Evidence-based Care ngc-guideline: [24]

Personal tools