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More Specific Terms


  • Treatment of disease with chemicals or pharmaceutical agents, generally used in reference to treatment of neoplastic disease.



  • curable by chemotherapy
  • chemotherapy is beneficial
  • chemotherapy may have some benefit



  • see specific agent
  • generally toxicity to rapidly dividing cells:


  • * Generally, chemotherapy effective on replicating cells.

  • Mechanism of chemotherapy failure:
  • decreased drug activation
  • increased drug inactivation
  • increased production of target enzyme
  • no age-associated resistance to chemotherapy [9]


More General Terms

Additional Terms


  1. Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015
  2. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 678-680
  3. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 527
  4. Bargou R et al. Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science 2008 Aug 15; 321:974. PMID: [1]
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  9. Geriatric Review Syllabus, 8th edition (GRS8) Durso SC and Sullivan GN (eds) American Geriatrics Society, 2013
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  11. Daenen LGM et al Increased Plasma Levels of Chemoresistance-Inducing Fatty Acid 16:4(n-3) After Consumption of Fish and Fish Oil. JAMA Oncol. Published online April 02, 2015. <PubMed> PMID: [10] <Internet> [11]
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  14. Maggiore RJ, Dale W, Gross CP et al Polypharmacy and potentially inappropriate medication use in older adults with cancer undergoing chemotherapy: effect on chemotherapy-related toxicity and hospitalization during treatment. J Am Geriatr Soc. 2014 Aug;62(8):1505-12. PMID: Free PMC Article&dopt=Abstract
  15. Klepin HD, Pitcher BN, Ballman KV et al Comorbidity, chemotherapy toxicity, and outcomes among older women receiving adjuvant chemotherapy for breast cancer on a clinical trial: CALGB 49907 and CALGB 361004 (alliance). J Oncol Pract. 2014 Sep;10(5):e285-92. PMID: Free PMC Article&dopt=Abstract
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  17. Kano M et al. AMH/MIS as a contraceptive that protects the ovarian reserve during chemotherapy. Proc Natl Acad Sci U S A 2017 Feb 28; 114:E1688. <PubMed> PMID: Free PMC Article&dopt=Abstract <Internet> [15]
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  21. National Guideline Clearinghouse
    - American Society of Clinical Oncology 2008 clinical practice guideline update: use of chemotherapy and radiation therapy protectants ngc-guideline: [21]
    - Guideline for the prevention of acute chemotherapy-induced nausea and vomiting in pediatric cancer patients: a focused update. Pediatric Oncology Group of Ontario ngc-guideline: [22]
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