Chemoprophylaxis For Tuberculosis

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Contents

Management

  • a positive TST conversion within 2 years regardless of age
  • persons with a history of untreated TB or radiographic evidence of previous TB
  • all TST-positive individuals < 35 years of age.
  • persons with a positive TST who are at high risk for TB
  • new TST converters > 15 mm on serial testing
  • household members & close contacts of patients with TB who have a positive TST (treat until PPD is negative 12 weeks later)
  • twice weekly schedule (directly observed therapy) is an alternative [9]
  • otherwise healthy, >= 12 years of age
  • high risk of developing TB
  • weekly dosing
  • directly observed therapy

More General Terms

Additional Terms

References

  1. Manual of Medical Therapeutics, 28th ed, Ewald & McKenzie (eds), Little, Brown & Co, Boston, 1995
  2. Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 183-86
  3. American Thoracic Society: Am J Crit Care Med 149:1359-1374 1994
  4. Medical Knowledge Self Assessment Program (MKSAP) 11, 14, American College of Physicians, Philadelphia 1998, 2006
  5. Prescriber's Letter 7(7):40 2000
  6. Kaiser Permanente, Northern California, Infection Control Update, 9/2000
  7. Journal Watch 21(19):155, 2001 MMWR Morb Mort Wkly Rep 50:733, 2001
  8. Prescriber's Letter 10(9):50 2003
  9. Lardizabal A et al, Enhancement of treatment completion for latent tuberculosis infection with 4 months of rifampin. Chest 2006, 130:1712 PMID: [1]
    - Ashkin D et al, Consider rifampin BUT be cautious Chest 2006, 130:1638 PMID: [2]
  10. American Thoracic Society, Targeted Testing and Treatment of Latent Tuberculosis Infection, Am J Respir Crit Care Med 161:S221, 2000 [3] [4]
  11. CDC Press Release May 16m 2011 Session B9, oral presentation: Sterling, PREVENT TB: Results of a 12-Dose, Once-Weekly Treatment of Latent Tuberculosis Infection (LTBI) [5]
    - Sterling TR et al Three Months of Rifapentine and Isoniazid for Latent Tuberculosis Infection N Engl J Med 2011; 365:2155-2166 <PubMed> PMID: [6] <Internet> [7]
    - Dye C Practical Preventive Therapy for Tuberculosis? N Engl J Med 2011; 365:2230-2231 <PubMed> PMID: [8] <Internet> [9]
    - Centers for Disease Control and Prevention Recommendations for Use of an Isoniazid-Rifapentine Regimen with Direct Observation to Treat Latent Mycobacterium tuberculosis Infection MMWR. December 9, 2011 / 60(48);1650-1653 [10]
    - Prescriber's Letter 19(2): 2012 Detail-Document#: [11] (subscription needed) [12]
  12. Anger HA et al. Active case finding and prevention of tuberculosis among a cohort of contacts exposed to infectious tuberculosis cases in New York City. Clin Infect Dis 2012 May 1; 54:1287 PMID: [13]
  13. Centers for Disease Control and Prevention (CDC). Recommendations for use of an isoniazid-rifapentine regimen with direct observation to treat latent Mycobacterium tuberculosis infection. MMWR Morb Mortal Wkly Rep. 2011 Dec 9;60(48):1650-3. PMID: [14]
  14. Centers for Disease Control and Prevention Treatment for Latent TB Infection [15]

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